Two Genomes, One Cell: Mitochondrial-Nuclear Coordination

All eukaryotic cells contain distinct two genomes, the nuclear genome and the mitochondrial genome. The communication between mitochondria and the nucleus within the cell is vital for coordinating cellular responses to internal and external cues. Recent efforts in our lab focus are to address:

• How do mitochondria interact with intercellular organelles?
• How do mitochondria regulate gene activity and cell fate?

Mitochondria Communicating Across Cells

By understanding the specific components and mechanisms through which mitochondria influence other cells via cargo of extracellular vehicles (eg, nucleic acids, lipids, and proteins), we hope to reveal new drivers/triggers of cardiovascular pathogenesis. Our research focuses on implementing advanced secretome analysis techniques to uncover these mitochondrial DAMPs. An improved molecular understanding of danger signaling might enable more effective cardio-protection post-sepsis.